en
Scientific article
Open access
English

A non-cell-autonomous actin redistribution enables isotropic retinal growth

Published inPLoS biology, vol. 16, no. 8, p. e2006018
Publication date2018-08-10
First online date2018-08-10
Abstract

Tissue shape is often established early in development and needs to be scaled isotropically during growth. However, the cellular contributors and ways by which cells interact tissue-wide to enable coordinated isotropic tissue scaling are not yet understood. Here, we follow cell and tissue shape changes in the zebrafish retinal neuroepithelium, which forms a cup with a smooth surface early in development and maintains this architecture as it grows. By combining 3D analysis and theory, we show how a global increase in cell height can maintain tissue shape during growth. Timely cell height increase occurs concurrently with a non-cell-autonomous actin redistribution. Blocking actin redistribution and cell height increase perturbs isotropic scaling and leads to disturbed, folded tissue shape. Taken together, our data show how global changes in cell shape enable isotropic growth of the developing retinal neuroepithelium, a concept that could also apply to other systems.

eng
Affiliation Not a UNIGE publication
Funding
  • The Francis Crick Institute - [10317]
  • Versus Arthritis - [FC001317]
  • Cancer Research UK - [21144]
  • Wellcome Trust -
Citation (ISO format)
MATEJČIĆ, Marija, SALBREUX, Guillaume, NORDEN, Caren. A non-cell-autonomous actin redistribution enables isotropic retinal growth. In: PLoS biology, 2018, vol. 16, n° 8, p. e2006018. doi: 10.1371/journal.pbio.2006018
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1544-9173
14views
3downloads

Technical informations

Creation05/11/2024 9:27:00 AM
First validation05/15/2024 12:09:07 PM
Update time05/15/2024 12:09:07 PM
Status update05/15/2024 12:09:07 PM
Last indexation05/15/2024 12:09:27 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack