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Scientific article
Open access
English

Apical and Basal Matrix Remodeling Control Epithelial Morphogenesis

Published inDevelopmental cell, vol. 46, no. 1, p. 23-39.e5
Publication date2018-07
Abstract

Epithelial tissues can elongate in two dimensions by polarized cell intercalation, oriented cell division, or cell shape change, owing to local or global actomyosin contractile forces acting in the plane of the tissue. In addition, epithelia can undergo morphogenetic change in three dimensions. We show that elongation of the wings and legs of Drosophila involves a columnar-to-cuboidal cell shape change that reduces cell height and expands cell width. Remodeling of the apical extracellular matrix by the Stubble protease and basal matrix by MMP1/2 proteases induces wing and leg elongation. Matrix remodeling does not occur in the haltere, a limb that fails to elongate. Limb elongation is made anisotropic by planar polarized Myosin-II, which drives convergent extension along the proximal-distal axis. Subsequently, Myosin-II relocalizes to lateral membranes to accelerate columnar-to-cuboidal transition and isotropic tissue expansion. Thus, matrix remodeling induces dynamic changes in actomyosin contractility to drive epithelial morphogenesis in three dimensions.

eng
Keywords
  • Drosophila
  • Epithelia
  • Extracellular matrix
  • Morphogenesis
Affiliation Not a UNIGE publication
Funding
  • The Francis Crick Institute - [10180]
  • Wellcome Trust -
  • Cancer Research UK - [21144]
  • Versus Arthritis - [FC001180]
  • Francis Crick Institute -
  • Medical Research Council -
Citation (ISO format)
DIAZ-DE-LA-LOZA, Maria-del-Carmen et al. Apical and Basal Matrix Remodeling Control Epithelial Morphogenesis. In: Developmental cell, 2018, vol. 46, n° 1, p. 23–39.e5. doi: 10.1016/j.devcel.2018.06.006
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Article (Published version)
Identifiers
ISSN of the journal1534-5807
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