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Scientific article
Open access
English

Guideline adherence in febrile children below 3 months visiting European Emergency Departments : an observational multicenter study

CollaboratorsPosfay Barbe, Klara
Published inEuropean journal of pediatrics, vol. 181, no. 12, p. 4199-4209
Errata
  • Erratum in : Tan CD, van der Walle EEPL, Vermont CL, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Tsolia M, Yeung S, Zenz W, Zavadska D, Moll HA; PERFORM consortium (Personalised Risk assessment in febrile children to optimize Real-life Management across the European Union). Correction to: Guideline adherence in febrile children below 3 months visiting European Emergency Departments: an observational multicenter study. Eur J Pediatr. 2022 Dec;181(12):4211-4214. doi: 10.1007/s00431-022-04664-9.
  • DOI : 10.1007/s00431-022-04664-9
  • PMID : 36269427
Publication date2022-12
First online date2022-09-30
Abstract

Unlabelled: Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. There is practice variation in management due to differences in guidelines and their usage and adherence. We aimed to assess whether management in febrile children below 3 months attending European Emergency Departments (EDs) was according to the guidelines for fever. This study is part of the MOFICHE study, which is an observational multicenter study including routine data of febrile children (0-18 years) attending twelve EDs in eight European countries. In febrile children below 3 months (excluding bronchiolitis), we analyzed actual management compared to the guidelines for fever. Ten EDs applied the (adapted) NICE guideline, and two EDs applied local guidelines. Management included diagnostic tests, antibiotic treatment, and admission. We included 913 children with a median age of 1.7 months (IQR 1.0-2.3). Management per ED varied as follows: use of diagnostic tests 14-83%, antibiotic treatment 23-54%, admission 34-86%. Adherence to the guideline was 43% (374/868) for blood cultures, 29% (144/491) for lumbar punctures, 55% (270/492) for antibiotic prescriptions, and 67% (573/859) for admission. Full adherence to these four management components occurred in 15% (132/868, range 0-38%), partial adherence occurred in 56% (484/868, range 35-77%).

Conclusion: There is large practice variation in management. The guideline adherence was limited, but highest for admission which implies a cautious approach. Future studies should focus on guideline revision including new biomarkers in order to optimize management in young febrile children.

What is known: • Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. • There is practice variation in management of young febrile children due to differences in guidelines and their usage and adherence.

What is new: • Full guideline adherence is limited, whereas partial guideline adherence is moderate in febrile children below 3 months across Europe. • Guideline revision including new biomarkers is needed to improve management in young febrile children.

eng
Keywords
  • Children
  • Emergency care
  • Fever
  • Guideline
  • Pediatrics
  • Child
  • Humans
  • Infant
  • Guideline Adherence
  • Fever / therapy
  • Fever / drug therapy
  • Emergency Service, Hospital
  • Bacterial Infections / diagnosis
  • Bacterial Infections / drug therapy
  • Anti-Bacterial Agents / therapeutic use
  • Biomarkers
Citation (ISO format)
TAN, Chantal D et al. Guideline adherence in febrile children below 3 months visiting European Emergency Departments : an observational multicenter study. In: European journal of pediatrics, 2022, vol. 181, n° 12, p. 4199–4209. doi: 10.1007/s00431-022-04606-5
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Article (Published version)
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Erratum
Identifiers
ISSN of the journal0340-6199
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Technical informations

Creation03/04/2024 11:49:56 AM
First validation05/07/2024 2:51:26 PM
Update time05/07/2024 2:51:26 PM
Status update05/07/2024 2:51:26 PM
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