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Scientific article
Open access
English

Para-infectious brain injury in covid-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Published inNature communications, vol. 14, no. 1, 8487
Errata
  • Erratum in : Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG; ISARIC4C Investigators; COVID-CNS Consortium; Taams LS, Menon DK. Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2024 Apr 4;15(1):2918.
  • PMID : 38575615
Publication date2023-12-22
First online date2023-12-22
Abstract

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely.

eng
Keywords
  • Autoantibodies
  • Biomarkers
  • Brain Injuries
  • COVID-19 Serotherapy
  • COVID-19 / complications
  • Cytokines
  • Follow-Up Studies
  • Glial Fibrillary Acidic Protein
  • Humans
  • Inflammation Mediators
Citation (ISO format)
MICHAEL, Benedict D. et al. Para-infectious brain injury in covid-19 persists at follow-up despite attenuated cytokine and autoantibody responses. In: Nature communications, 2023, vol. 14, n° 1, p. 8487. doi: 10.1038/s41467-023-42320-4
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ISSN of the journal2041-1723
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Technical informations

Creation01/25/2024 1:15:58 PM
First validation04/24/2024 1:48:50 PM
Update time04/24/2024 1:48:50 PM
Status update04/24/2024 1:48:50 PM
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