en
Scientific article
Review
Open access
English

Drosophila models of sporadic parkinson’s disease

ContributorsNagoshi, Emiorcid
Published inInternational journal of molecular sciences, vol. 19, no. 11, p. 1-26; 3343
Publication date2018-10-26
First online date2018-10-26
Abstract

Parkinson’s disease (PD) is the most common cause of movement disorders and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is increasingly recognized as a complex group of disorders presenting widely heterogeneous symptoms and pathology. With the exception of the rare monogenic forms, the majority of PD cases result from an interaction between multiple genetic and environmental risk factors. The search for these risk factors and the development of preclinical animal models are in progress, aiming to provide mechanistic insights into the pathogenesis of PD. This review summarizes the studies that capitalize on modeling sporadic (i.e., nonfamilial) PD using Drosophila melanogaster and discusses their methodologies, new findings, and future perspectives.

eng
Keywords
  • Drosophila
  • Animal model
  • Sporadic Parkinson’s disease
Citation (ISO format)
NAGOSHI, Emi. <i>Drosophila </i>models of sporadic parkinson’s disease. In: International journal of molecular sciences, 2018, vol. 19, n° 11, p. 1–26. doi: 10.3390/ijms19113343
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ISSN of the journal1422-0067
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