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Scientific article
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Open access
English

Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms

Published inSTP pharma sciences, vol. 2, no. 2, p. 141-158
Publication date1992
Abstract

The authors review the literature dealing with the comparison of oral multiple-unit and single-unit sustained- release formulations. Some elements of gastro-intestinal physiology and the fate of dosage forms in vivo are presented. The gastro-intestinal transit time and the variability of both formulation principles are then considered in order to explain possible differences. The spreading of multiple-unit dosage forms throughout the gastro-intestinal tract is also examined. Finally, the interest of pharmacokinetic parameters for the comparison of oral sustained-release delivery system is discussed.

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Keywords
  • Sustained-release
  • Oral route
  • Multiple-unit dosage forms
  • Single-unit dosage forms
  • Gastro-intestinal transit
  • Gamma scintigraphy
  • Libération prolongée
  • Voie orale
  • Formes divisées
  • Formes monolithiques
  • Scintigraphie gamma
  • Transit gastro-intestinal
Citation (ISO format)
FOLLONIER, Nicolas, DOELKER, Eric. Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms. In: STP pharma sciences, 1992, vol. 2, n° 2, p. 141–158.
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Article (Published version)
accessLevelPublic
Identifiers
  • PID : unige:176521
ISSN of the journal1157-1489
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