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Scientific article
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Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles

Publication date2020-10-05
First online date2020-10-05
Abstract

Reptiles exhibit a spectacular diversity of skin colors generated by interactions among black melanophores, red and yellow xanthophores, as well as iridophores producing structural colors. Here, we use the corn snake to investigate the generative mechanisms of skin colors beyond the zebrafish model. We perform sequencing and annotation of a nearly chromosome-quality genome of the corn snake, followed by mapping-by-sequencing and identification of a mutation in the lysosomal trafficking regulator gene ( LYST ) in the lavender variant with strongly affected coloration. Further analyses indicate that color-producing organelles of all chromatophores are substantially impacted in the LYST mutant, indicating that not only melanosomes, but also xanthosomes and iridosomes, are all lysosome-related organelles.

eng
Keywords
  • LYST
  • Chromatophores
  • Corn snake
  • Lysosome-related organelles
  • Pigmentation
Research group
Citation (ISO format)
ULLATE AGOTE, Asier et al. Genome mapping of a <i>LYST </i>mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles. In: Proceedings of the National Academy of Sciences of the United States of America, 2020, vol. 117, n° 42, p. 26307–26317. doi: 10.1073/pnas.2003724117
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ISSN of the journal0027-8424
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