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Scientific article
English

Quality of life in elderly patients with venous thromboembolism assessed using patient-reported outcome measures

Published inJournal of thrombosis and haemostasis, vol. 21, no. 11, p. 3193-3202
Publication date2023-11
First online date2023-08-12
Abstract

Background: We aimed to evaluate the quality of life (QoL), using patient-reported outcome measures (PROMs), in elderly patients with venous thromboembolism (VTE) and to explore whether VTE complications (recurrence, bleeding, or postthrombotic syndrome) had an impact on later QoL.

Methods: We used data from the SWIss venous Thromboembolism COhort of older patients(SWITCO65+), a prospective multicenter cohort of patients aged ≥65 years with acute, symptomatic VTE. Primary outcome was changes in QoL up to 24 months, assessed using generic (36-Item Short-Form Health Survey), with physical (PCS) and mental component score (MCS), and disease-specific (Venous Insufficiency Epidemiological and Economic Study [VEINES]-QoL, [VEINES-Sym], and Pulmonary Embolism QoL) PROMs. PROM scores ranged from 0 to 100 points, higher scores indicating a better QoL. Longitudinal latent class analysis was used to group patients with similar PCS trajectories. Repeated-measures linear regression analyses were used to assess effects of VTE complications on changes in QoL scores.

Results: In 923 patients (median age, 75; male, 54%), 140 (15%) patients died, 97 (11%) experienced recurrent VTE, and 106 (12%) major bleeding during follow-up. Compared with patients with higher PCS trajectories, patients with lower PCS trajectories were more likely to be older, female, sicker, and less physically active. On average, generic and disease-specific QoL scores improved over time (+11% in PCS, +3% in MCS, +6% in VEINES QoL, and +16% in Pulmonary Embolism QoL at 3 months). VTE complications were always associated with significantly lower QoL scores (for VTE recurrence: PCS adjusted difference -2.57, 95% CI, -4.47 to -0.67).

Conclusion: Although QoL following VTE tended to improve over time, patients with VTE-related complications had lower QoL than patients without complications.

eng
Keywords
  • Elderly patients
  • Major bleeding
  • Patient-reported outcome measures
  • Quality of life
  • Venous thromboembolism
  • Aged
  • Humans
  • Male
  • Female
  • Quality of Life
  • Venous Thromboembolism / diagnosis
  • Prospective Studies
  • Hemorrhage
  • Venous Insufficiency
  • Pulmonary Embolism / diagnosis
  • Patient Reported Outcome Measures
Citation (ISO format)
DESCHAMPS, Justine et al. Quality of life in elderly patients with venous thromboembolism assessed using patient-reported outcome measures. In: Journal of thrombosis and haemostasis, 2023, vol. 21, n° 11, p. 3193–3202. doi: 10.1016/j.jtha.2023.07.022
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ISSN of the journal1538-7836
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