Scientific article

Hypophosphatémies de causes rares : approche diagnostique

Published inRevue médicale suisse, vol. 19, no. 823, p. 770-775
Publication date2023-04-19

Hypophosphatemia is common and may be overlooked due to its asymptomatic nature or non-specific symptoms. Two main mechanisms are at its origin: a shift towards the intracellular sector and an increase in urinary phosphate excretion. A measurement of the urinary phosphate reabsorption threshold allows a diagnostic orientation. Alongside common forms of parathyroid hormone-dependent hypophosphatemia, one should not ignore rare FGF23-mediated forms, in particular X-linked hypophosphatemic rickets. The treatment, above all etiological, also includes the administration of phosphate and, in the event of an excess of FGF23, supplementation with calcitriol. In cases of oncogenic osteomalacia and X-linked hypophosphatemic rickets, the use of burosumab, an anti-FGF23 antibody, must be considered.

  • Humans
  • Familial Hypophosphatemic Rickets / diagnosis
  • Familial Hypophosphatemic Rickets / etiology
  • Familial Hypophosphatemic Rickets / therapy
  • Fibroblast Growth Factors
  • Hypophosphatemia / diagnosis
  • Hypophosphatemia / etiology
  • Phosphates
  • Calcitriol
Citation (ISO format)
TROMBETTI, Andrea, FOKSTUEN, Siv, PARVEX, Paloma Maria. Hypophosphatémies de causes rares : approche diagnostique. In: Revue médicale suisse, 2023, vol. 19, n° 823, p. 770–775. doi: 10.53738/REVMED.2023.19.823.770
Main files (1)
Article (Published version)
accessLevelRestrictedaccessLevelPublic 10/20/2024
ISSN of the journal1660-9379

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