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Scientific article
English

Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features

Published inScience, vol. 383, no. 6685, eadj7026
Publication date2024-02-23
Abstract

In some mammals, notably humans, recombination occurs almost exclusively where the protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9 , such as birds and canids, recombination rates are elevated near promoter-like features. To determine whether PRDM9 directs recombination in nonmammalian vertebrates, we focused on an exemplar species with a single, intact PRDM9 ortholog, the corn snake ( Pantherophis guttatus ). Analyzing historical recombination rates along the genome and crossovers in pedigrees, we found evidence that PRDM9 specifies the location of recombination events, but we also detected a separable effect of promoter-like features. These findings reveal that the uses of PRDM9 and promoter-like features need not be mutually exclusive and instead reflect a tug-of-war that is more even in some species than others.

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Citation (ISO format)
HOGE, Carla et al. Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features. In: Science, 2024, vol. 383, n° 6685, p. eadj7026. doi: 10.1126/science.adj7026
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ISSN of the journal0036-8075
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