Scientific article
Open access

Somitic positional information guides self-organized patterning of snake scales

Published inScience advances, vol. 9, no. 24, eadf8834
Publication date2023-06-16

Two influential concepts in tissue patterning are Wolpert’s positional information and Turing’s self-organized reaction–diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional—by CRISPR-Cas9–mediated gene disruption—characterization of wild-type versus “scaleless” snakes reveals that the near-perfect hexagonal pattern of snake scales is established through interactions between RD in the skin and somitic positional information. First, we show that ventral scale development is guided by hypaxial somites and, second, that ventral scales and epaxial somites guide the sequential RD patterning of the dorsolateral scales. The RD intrinsic length scale evolved to match somite periodicity, ensuring the alignment of ribs and scales, both of which play a critical role in snake locomotion.

Research group
Citation (ISO format)
TZIKA, Athanasia et al. Somitic positional information guides self-organized patterning of snake scales. In: Science advances, 2023, vol. 9, n° 24, p. eadf8834. doi: 10.1126/sciadv.adf8834
Main files (1)
Article (Published version)
ISSN of the journal2375-2548

Technical informations

Creation04/12/2024 4:38:28 AM
First validation04/15/2024 11:54:12 AM
Update time04/15/2024 11:54:12 AM
Status update04/15/2024 11:54:12 AM
Last indexation05/06/2024 6:23:16 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack