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Scientific article
English

Pharmacological properties of the homomeric α7 receptor

Published inNeuroscience letters, vol. 146, no. 1, p. 87-90
Publication date1992-10
Abstract

The pharmacological properties of the α-bungarotoxin sensitive α7 neuronal nicotinic acetylcholine receptor (nAChR) were studied upon reconstitutio in Xenopus oocytes. Channels formed by α7 are about 10-fold more sensitive to nicotine and cytisine than to ACh but are little, if at all, activated by the ganglionic agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). Tubocurarine (TC) was found to act as a non-competitive inhibitor, whereas dihydro-β-erythroidine (DHβE) behaves as a pure competitive inhibitor whose blockade is fast and fully reversible. In addition, the α7 receptor displays a poor sensitivity to methonium salts. The pharmacological properties of the α7 channels are readily distinguishable from those of other identified neuronal nicotinic receptors.

eng
Keywords
  • Neuronal
  • Nicotinic acetylcholine receptor
  • Pharmacology
  • Electrophysiology
  • Xenopus oocyte
  • Alpha-Bungarotoxin
Citation (ISO format)
BERTRAND, Daniel, BERTRAND, Sonia, BALLIVET, Marc. Pharmacological properties of the homomeric α7 receptor. In: Neuroscience letters, 1992, vol. 146, n° 1, p. 87–90. doi: 10.1016/0304-3940(92)90179-B
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ISSN of the journal0304-3940
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