en
Scientific article
Review
Open access
English

A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

Published inComputational and Structural Biotechnology Journal, vol. 21, p. 4868-4886
Publication date2023
First online date2023-10-10
Abstract

Hydrogel scaffolds hold great promise for developing novel treatment strategies in the field of regenerative medicine. Within this context, silk fibroin (SF) has proven to be a versatile material for a wide range of tissue engineering applications owing to its structural and functional properties. In the present review, we report on the design and fabrication of different forms of SF-based scaffolds for tissue regeneration applications, particularly for skin, bone, and neural tissues. In particular, SF hydrogels have emerged as delivery systems for a wide range of bio-actives. Given the growing interest in the field, this review has a primary focus on the fabrication, characterization, and properties of SF hydrogels. We also discuss their potential for the delivery of drugs, stem cells, genes, peptides, and growth factors, including future directions in the field of SF hydrogel scaffolds.

eng
Keywords
  • Biofabrication
  • Cell therapy
  • Drug delivery
  • Hydrogels
  • Tissue engineering
  • Tissue regeneration
Citation (ISO format)
MADAPPURA, Alakananda Parassini, MADDURI, Srinivas. A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine. In: Computational and Structural Biotechnology Journal, 2023, vol. 21, p. 4868–4886. doi: 10.1016/j.csbj.2023.10.012
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2001-0370
11views
3downloads

Technical informations

Creation10/18/2023 1:44:33 PM
First validation03/27/2024 10:49:42 AM
Update time03/27/2024 10:49:42 AM
Status update03/27/2024 10:49:42 AM
Last indexation03/27/2024 10:50:02 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack