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Scientific article
English

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin

Publication date2015-10-21
First online date2015-10-21
Abstract

Significance

Staphylococcus aureus is a major cause of invasive bacterial infection. One prominent virulence factor is α-toxin, a protein that injures the cell by forming a damaging pore across the cell membrane. We conducted a genetic screen to identify host factors that control susceptibility to α-toxin. We discovered that several components of the adherens junction complex modulate α-toxin cytotoxicity. By eliminating expression of the junctional protein plekstrin-homology domain containing protein 7 (PLEKHA7), cells gained the ability to recover from α-toxin injury and mice lacking PLEKHA7 exhibited improved healing from S. aureus skin infection and enhanced survival of pneumonia. Our data suggest that targeting nonessential host epithelial junction components can reduce S. aureus morbidity by enhancing cellular resilience to α-toxin injury.

eng
Keywords
  • MRSA
  • PLEKHA7
  • Staphylococcus aureus
  • adherens junctions
  • α-toxin
Funding
  • NIAID NIH HHS - [F31 AI118212]
Citation (ISO format)
POPOV, Lauren et al. The adherens junctions control susceptibility to Staphylococcus <i>aureus</i> α-toxin. In: Proceedings of the National Academy of Sciences of the United States of America, 2015, vol. 112, n° 46, p. 14337–14342. doi: 10.1073/pnas.1510265112
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Article (Published version)
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Identifiers
ISSN of the journal0027-8424
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