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Scientific article
Review
Open access
English

Mesenchymal stem cells in nerve tissue engineering : bridging nerve gap injuries in large animals

Published inInternational journal of molecular sciences, vol. 24, no. 9, 7800
Publication date2023-04-25
First online date2023-04-25
Abstract

Cell-therapy-based nerve repair strategies hold great promise. In the field, there is an extensive amount of evidence for better regenerative outcomes when using tissue-engineered nerve grafts for bridging severe gap injuries. Although a massive number of studies have been performed using rodents, only a limited number involving nerve injury models of large animals were reported. Nerve injury models mirroring the human nerve size and injury complexity are crucial to direct the further clinical development of advanced therapeutic interventions. Thus, there is a great need for the advancement of research using large animals, which will closely reflect human nerve repair outcomes. Within this context, this review highlights various stem cell-based nerve repair strategies involving large animal models such as pigs, rabbits, dogs, and monkeys, with an emphasis on the limitations and strengths of therapeutic strategy and outcome measurements. Finally, future directions in the field of nerve repair are discussed. Thus, the present review provides valuable knowledge, as well as the current state of information and insights into nerve repair strategies using cell therapies in large animals.

eng
Keywords
  • Schwann cells
  • Cell therapy
  • Growth factors
  • Large animal models
  • Nerve guidance conduit
  • Nerve injury
  • Nerve regeneration
  • Stem cells
  • Humans
  • Animals
  • Rabbits
  • Dogs
  • Swine
  • Tissue Engineering
  • Schwann Cells / physiology
  • Peripheral Nervous System Diseases
  • Mesenchymal Stem Cells
  • Stem Cells
  • Trauma, Nervous System
  • Nerve Regeneration / physiology
  • Peripheral Nerve Injuries / therapy
  • Sciatic Nerve / injuries
Citation (ISO format)
LISCHER, Mirko et al. Mesenchymal stem cells in nerve tissue engineering : bridging nerve gap injuries in large animals. In: International journal of molecular sciences, 2023, vol. 24, n° 9, p. 7800. doi: 10.3390/ijms24097800
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Article (Published version)
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ISSN of the journal1422-0067
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Creation05/16/2023 12:26:07 PM
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