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Scientific article
Open access
English

Involvement of interleukin-3 in delayed-type hypersensitivity

Published inBlood, vol. 91, no. 3, p. 778-783
Publication date1998-02-01
Abstract

The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity.

eng
Keywords
  • Dermatitis, Contact
  • Hematopoiesis
  • Hypersensitivity, Delayed
  • Interleukin-3 / deficiency
  • Interleukin-3 / genetics
  • Interleukin-3 / physiology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutagenesis
  • Neoplasms, Experimental / immunology
  • Skin / immunology
  • Skin / pathology
  • T-Lymphocytes / immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
MACH, Nicolas et al. Involvement of interleukin-3 in delayed-type hypersensitivity. In: Blood, 1998, vol. 91, n° 3, p. 778–783.
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Article (Published version)
Identifiers
ISSN of the journal0006-4971
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