Cytokine-secreting tumor cell vaccines

Mach, Nicolas; Dranoff, G

doi:10.1016/s0952-7915(00)00144-8

Scientific article

Review

English

Cytokine-secreting tumor cell vaccines

ContributorsMach, Nicolas; Dranoff, G

Published inCurrent opinion in immunology, vol. 12, no. 5, p. 571-575

Publication date2000-10

Abstract

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

Keywords

Animals
Cancer Vaccines / immunology
Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
Humans
Interleukin-12 / metabolism

Affiliation entities

Not a UNIGE publication

Research groups

Immunothérapie (654)

Citation (ISO format)

MACH, Nicolas, DRANOFF, G. Cytokine-secreting tumor cell vaccines. In: Current opinion in immunology, 2000, vol. 12, n° 5, p. 571–575. doi: 10.1016/s0952-7915(00)00144-8

Article (Published version)

Identifiers

PID : unige:175795
DOI : 10.1016/s0952-7915(00)00144-8
PMID : 11007361

Additional URL for this publicationhttps://www.sciencedirect.com/science/article/pii/S0952791500001448

Journal ISSN0952-7915

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Creation06/12/2023 14:39:44

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Cytokine-secreting tumor cell vaccines

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