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Scientific article
Review
English

Cytokine-secreting tumor cell vaccines

Published inCurrent opinion in immunology, vol. 12, no. 5, p. 571-575
Publication date2000-10
Abstract

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

eng
Keywords
  • Animals
  • Cancer Vaccines / immunology
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
  • Humans
  • Interleukin-12 / metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
MACH, Nicolas, DRANOFF, G. Cytokine-secreting tumor cell vaccines. In: Current opinion in immunology, 2000, vol. 12, n° 5, p. 571–575. doi: 10.1016/s0952-7915(00)00144-8
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Article (Published version)
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ISSN of the journal0952-7915
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