Scientific article

Inflow effect correction in fast gradient-echo perfusion imaging

Published inMagnetic resonance in medicine, vol. 50, no. 5, p. 885-891
Publication date2003-11

The purposes of this study were to assess the extent of the inflow effect on signal intensity (SI) for fast gradient-recalled-echo (GRE) sequences used to observe first-pass perfusion, and to develop and validate a correction method for this effect. A phantom experiment with a flow apparatus was performed to determine SI as a function of Gd-DTPA concentration for various velocities. Subsequently a flow-sensitive calibration method was developed, and validated on bolus injections into an open-circuit flow apparatus and in vivo. It is shown that calibration methods based on static phantoms are not appropriate for accurate signal-to-concentration conversion in images affected by high flow. The flow-corrected calibration method presented here can be used to improve the accuracy and robustness of the arterial input function (AIF) determination for tissue perfusion quantification using MRI and contrast media.

  • Blood Flow Velocity
  • Calibration
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Image Processing, Computer-Assisted
  • Kidney / pathology
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Perfusion
  • Phantoms, Imaging
Citation (ISO format)
IVANCEVIC, Marko Kresimir et al. Inflow effect correction in fast gradient-echo perfusion imaging. In: Magnetic resonance in medicine, 2003, vol. 50, n° 5, p. 885–891. doi: 10.1002/mrm.10633
Main files (1)
Article (Published version)
ISSN of the journal0740-3194

Technical informations

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