en
Doctoral thesis
Open access
English

Protein-Nanoparticle Interactions: In Vitro-In Vivo Correlation and Implications for Corona Formation

ContributorsMarques, Cintia
Number of pages228
Imprimatur date2023
Defense date2023
Abstract

This thesis aims to comprehensively investigate the intricate interactions between NPs of different surface charges and plasma proteins, to understand the process of PC formation and its influence on the behavior of these NPs. The primary goal was to discern the effect of NP surface charge on the composition of the PC and establish a correlation between this composition and key proteins observed in vivo. Additionally, in vitro studies were designed to explore the in vivo-in vitro correlation of protein adsorption, thereby exploring the potential to simplify further protein corona investigations.

freeng
Keywords
  • Protein corona
  • Protein interactions
  • Charge
  • Hydrophobicity
  • Molecular weight
  • Conformational stability
Citation (ISO format)
MARQUES, Cintia. Protein-Nanoparticle Interactions: In Vitro-In Vivo Correlation and Implications for Corona Formation. 2023. doi: 10.13097/archive-ouverte/unige:175674
Main files (1)
Thesis
accessLevelPublic
Secondary files (1)
Identifiers
26views
2downloads

Technical informations

Creation03/15/2024 11:07:30 AM
First validation03/18/2024 8:33:37 AM
Update time03/18/2024 8:33:37 AM
Status update03/18/2024 8:33:37 AM
Last indexation05/08/2024 2:17:00 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack