Scientific article
Open access

Volume status assessment by lung ultrasound in end-stage kidney disease : a systematic review

Published inCanadian journal of kidney health and disease, vol. 10, 20543581231217853
Publication date2023
First online date2023-12-25

Purpose of review: Lung ultrasound is a noninvasive bedside technique that can accurately assess pulmonary congestion by evaluating extravascular lung water. This technique is expanding and is easily available. Our primary outcome was to compare the efficacy of volume status assessment by lung ultrasound with clinical evaluation, echocardiography, bioimpedance, or biomarkers. The secondary outcomes were all-cause mortality and cardiovascular events.

Sources of information: We conducted a MEDLINE literature search for observational and randomized studies with lung ultrasound in patients on maintenance dialysis.

Methods: From a total of 2363 articles, we included 28 studies (25 observational and 3 randomized). The correlation coefficients were pooled for each variable of interest using the generic inverse variance method with a random effects model. Among the clinical parameters, New York Heart Association Functional Classification of Heart Failure status and lung auscultation showed the highest correlation with the number of B-lines on ultrasound, with a pooledrcorrelation coefficient of .57 and .36, respectively. Among echocardiographic parameters, left ventricular ejection fraction and inferior vena cava index had the strongest correlation with the number of B-lines, with a pooledrcoefficient of .35 and .31, respectively. Three randomized studies compared a lung ultrasound-guided approach with standard of care on hard clinical endpoints. Although patients in the lung ultrasound group achieved better decongestion and blood pressure control, there was no difference between the 2 management strategies with respect to death from any cause or major adverse cardiovascular events.

Key findings: Lung ultrasound may be considered for the identification of patients with subclinical volume overload. Trials did not show differences in clinically important outcomes. The number of studies was small and many were of suboptimal quality.

Limitations: The included studies were heterogeneous and of relatively limited quality.

  • Chronic kidney disease
  • Dialysis
  • Lung ultrasound
  • Major adverse cardiovascular events
  • Mortality
  • Volume assessment
Citation (ISO format)
KHARAT, Aileen et al. Volume status assessment by lung ultrasound in end-stage kidney disease : a systematic review. In: Canadian journal of kidney health and disease, 2023, vol. 10, p. 20543581231217853. doi: 10.1177/20543581231217853
Main files (1)
Article (Published version)
ISSN of the journal2054-3581

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