en
Scientific article
Open access
English

Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their household contacts

Published inMicrobiology spectrum, vol. 11, no. 6, e01275-23
Publication date2023-12-12
First online date2023-10-27
Abstract

Colonization with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) often precedes infections and is therefore considered as a great threat for public health. Here, we studied the gut microbiome dynamics in eight index patients colonized with ESBL-PE after hospital discharge and the impact of exposure to this index patient on the gut microbiome dynamics of their household contacts. We showed that the microbiome composition from index patients is different from their household contacts upon hospital discharge and that, in some of the index patients, their microbiome composition over time shifted toward the composition of their household contacts. In contrast, household contacts showed a stable microbiome composition over time irrespective of low-level extended-spectrum beta-lactamase-producingEscherichia coli(ESBL-Ec) or extended-spectrum beta-lactamase-producingKlebsiella pneumoniae(ESBL-Kp) gut colonization, suggesting that, in healthy microbiomes, colonization resistance is able to prevent ESBL-PE expansion.

eng
Keywords
  • ESBL-Enterobacterales
  • Gut microbiome dynamics
  • Household contacts
  • Index patient
  • Humans
  • Gastrointestinal Microbiome
  • Patient Discharge
  • Beta-Lactamases
  • Escherichia coli
  • Klebsiella pneumoniae
  • Hospitals
  • Anti-Bacterial Agents
Citation (ISO format)
TOP, Janetta et al. Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their household contacts. In: Microbiology spectrum, 2023, vol. 11, n° 6, p. e01275–23. doi: 10.1128/spectrum.01275-23
Main files (1)
Article (Published version)
Secondary files (2)
Identifiers
ISSN of the journal2165-0497
25views
2downloads

Technical informations

Creation01/11/2024 10:12:24 AM
First validation03/12/2024 10:27:25 AM
Update time03/12/2024 10:27:25 AM
Status update03/12/2024 10:27:25 AM
Last indexation05/06/2024 6:08:58 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack