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A focus on yeast mating: From pheromone signaling to cell-cell fusion

Published inSeminars in cell & developmental biology, vol. 133, p. 83-95
Publication date2023-01
Abstract

Cells live in a chemical environment and are able to orient towards chemical cues. Unicellular haploid fungal cells communicate by secreting pheromones to reproduce sexually. In the yeast models Saccharomyces cerevisiae and Schizosaccharomyces pombe, pheromonal communication activates similar pathways composed of cognate G- protein-coupled receptors and downstream small GTPase Cdc42 and MAP kinase cascades. Local pheromone release and sensing, at a mobile surface polarity patch, underlie spatial gradient interpretation to form pairs between two cells of distinct mating types. Concentration of secretion at the point of cell-cell contact then leads to local cell wall digestion for cell fusion, forming a diploid zygote that prevents further fusion attempts. A number of asymmetries between mating types may promote efficiency of the system. In this review, we present our current knowledge of pheromone signaling in the two model yeasts, with an emphasis on how cells decode the pheromone signal spatially and ultimately fuse together. Though overall pathway architectures are similar in the two species, their large evolutionary distance allows to explore how conceptually similar solutions to a general biological problem can arise from divergent molecular components

eng
Keywords
  • Cdc42 GTPase
  • Cell fusion
  • Chemotropism
  • MAPK signaling
  • Mating
  • Pheromone signaling
Affiliation Not a UNIGE publication
Citation (ISO format)
SIEBER, Boris, CORONAS-SERNA, Julia María, MARTIN, Sophie. A focus on yeast mating: From pheromone signaling to cell-cell fusion. In: Seminars in cell & developmental biology, 2023, vol. 133, p. 83–95. doi: 10.1016/j.semcdb.2022.02.003
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ISSN of the journal1084-9521
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