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Scientific article
Open access
English

TEX15 associates with MILI and silences transposable elements in male germ cells

Published inGenes & development, vol. 34, no. 11-12, p. 745-750
Publication date2020-06-01
First online date2020-05-07
Abstract

DNA methylation is a major silencing mechanism of transposable elements (TEs). Here we report that TEX15, a testis-specific protein, is required for TE silencing. TEX15 is expressed in embryonic germ cells and functions during genome-wide epigenetic reprogramming. The Tex15 mutant exhibits DNA hypomethylation in TEs at a level similar to Mili and Dnmt3c but not Miwi2 mutants. TEX15 is associated with MILI in testis. As loss of Tex15 causes TE desilencing with intact piRNA production, our results identify TEX15 as a new essential epigenetic regulator that may function as a nuclear effector of MILI to silence TEs by DNA methylation.

eng
Keywords
  • DNA methylation
  • MILI
  • TEX15
  • Epigenetics
  • Spermatogenesis
  • Transposable element
Citation (ISO format)
YANG, Fang et al. TEX15 associates with MILI and silences transposable elements in male germ cells. In: Genes & development, 2020, vol. 34, n° 11-12, p. 745–750. doi: 10.1101/gad.335489.119
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ISSN of the journal0890-9369
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