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Scientific article
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English

Intercellular communication in airway epithelial cell regeneration : potential roles of connexins and pannexins

Published inInternational journal of molecular sciences, vol. 24, no. 22, 16160
Publication date2023-11-10
First online date2023-11-10
Abstract

Connexins and pannexins are transmembrane proteins that can form direct (gap junctions) or indirect (connexons, pannexons) intercellular communication channels. By propagating ions, metabolites, sugars, nucleotides, miRNAs, and/or second messengers, they participate in a variety of physiological functions, such as tissue homeostasis and host defense. There is solid evidence supporting a role for intercellular signaling in various pulmonary inflammatory diseases where alteration of connexin/pannexin channel functional expression occurs, thus leading to abnormal intercellular communication pathways and contributing to pathophysiological aspects, such as innate immune defense and remodeling. The integrity of the airway epithelium, which is the first line of defense against invading microbes, is established and maintained by a repair mechanism that involves processes such as proliferation, migration, and differentiation. Here, we briefly summarize current knowledge on the contribution of connexins and pannexins to necessary processes of tissue repair and speculate on their possible involvement in the shaping of the airway epithelium integrity.

eng
Keywords
  • Connexins
  • Epithelial differentiation
  • Epithelial repair
  • Epithelial signaling
  • Intercellular communication
  • Lungs
  • Pannexins
  • Humans
  • Connexins / metabolism
  • Gap Junctions / metabolism
  • Cell Communication / physiology
  • Ion Channels / metabolism
  • Lung Diseases / metabolism
  • Epithelial Cells / metabolism
Citation (ISO format)
BADAOUI, Mehdi, CHANSON, Marc. Intercellular communication in airway epithelial cell regeneration : potential roles of connexins and pannexins. In: International journal of molecular sciences, 2023, vol. 24, n° 22, p. 16160. doi: 10.3390/ijms242216160
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ISSN of the journal1422-0067
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