en
Scientific article
Review
English

Role and organization of the actin cytoskeleton during cell-cell fusion

ContributorsMartin, Sophieorcid
Published inSeminars in cell & developmental biology, vol. 60, p. 121-126
Publication date2016-12
Abstract

Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes. This process requires fusogenic machineries to promote plasma membrane merging, and also relies on the organization of dedicated sub-cortical cytoskeletal assemblies. This review describes the role of actin structures, so called actin fusion foci, essential for the fusion of two distinct cell types: Drosophila myoblast cells, which fuse to form myotubes, and sexually differentiated cells of the fission yeast Schizosaccha-romyces pombe, which fuse to form a zygote. I describe the respective composition and organization of the two structures, discuss their proposed role in promoting plasma membrane apposition, and consider the universality of similar structures for cell-cell fusion.

eng
Keywords
  • Actin fusion focus
  • Arp2/3
  • Cell fusion
  • Drosophila
  • Fertilization
  • Formin
  • Myoblast
  • Schizosaccharomyces pombe
Affiliation Not a UNIGE publication
Citation (ISO format)
MARTIN, Sophie. Role and organization of the actin cytoskeleton during cell-cell fusion. In: Seminars in cell & developmental biology, 2016, vol. 60, p. 121–126. doi: 10.1016/j.semcdb.2016.07.025
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Article (Published version)
accessLevelRestricted
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ISSN of the journal1084-9521
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