en
Scientific article
Open access
English

Blood proteome of acute intracranial hemorrhage in infant victims of abusive head trauma

Published inProteomics, vol. 23, no. 3-4, 2200078
Publication date2023-02
First online date2022-12-28
Abstract

Abusive head trauma (AHT) is a leading cause of mortality and morbidity in infants. While the reported incidence is close to 40 cases per 100'000 births/year, misdiagnoses are commonly observed in cases with atypical, subacute, or chronic presentation. Currently, standard clinical evaluation of inflicted intracranial hemorrhagic injury (ICH) in infants urgently requires a screening test able to identify infants who need additional investigations. Blood biomarkers characteristic of AHT may assist in detecting these infants, improving prognosis through early medical care. To date, the application of innovative omics technologies in retrospective studies of AHT in infants is rare, due also to the blood serum and cerebrospinal fluid of AHT cases being scarce and not systematically accessible. Here, we explored the circulating blood proteomes of infants with severe AHT and their atraumatic controls. We discovered 165 circulating serum proteins that display differential changes in AHT cases compared with atraumatic controls. The peripheral blood proteomes of pediatric AHT commonly reflect: (i) potentially secreted proteome from injured brain, and (ii) proteome dysregulated in the system's circulation by successive biological events following acute ICH. This study opens up a novel opportunity for research efforts in clinical screening of AHT cases.

eng
Keywords
  • Pediatric abusive head trauma
  • Postmortem blood
  • Serum proteomics
  • Humans
  • Infant
  • Child
  • Proteome
  • Retrospective Studies
  • Child Abuse / diagnosis
  • Craniocerebral Trauma / diagnosis
  • Craniocerebral Trauma / epidemiology
  • Intracranial Hemorrhages / diagnosis
Citation (ISO format)
WISKOTT, Kim et al. Blood proteome of acute intracranial hemorrhage in infant victims of abusive head trauma. In: Proteomics, 2023, vol. 23, n° 3-4, p. 2200078. doi: 10.1002/pmic.202200078
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ISSN of the journal1615-9853
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