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Scientific article
Review
English

Autoregulation and repair in microtubule homeostasis

Published inCurrent opinion in cell biology, vol. 56, p. 80-87
Publication date2019-02
Abstract

Even in the face of damaging insults, most cells maintain stability over time through multiple homeostatic pathways, including maintenance of the microtubule cytoskeleton that is fundamental to numerous cellular processes. The dynamic instability—perpetual growth and shrinkage—is the best-known microtubule regulatory pathway, which allows rapid rebuilding of the microtubule cytoskeleton in response to internal or external cues. Much less investigated is homeostatic regulation through availability of α-β tubulin heterodimers—microtubules’ main building blocks—which influences total mass and dynamic behavior of microtubules. Finally, the most recently discovered is microtubule homeostasis through self-repair, where new GTP-bound tubulin heterodimers replace the lost ones in the microtubule lattice. In this review we try to integrate our current knowledge on how dynamic instability, regulation of tubulin mass, and self-repair work together to achieve microtubule homeostasis.

eng
Affiliation Not a UNIGE publication
Citation (ISO format)
GASIC, Ivana, MITCHISON, Timothy J. Autoregulation and repair in microtubule homeostasis. In: Current opinion in cell biology, 2019, vol. 56, p. 80–87. doi: 10.1016/j.ceb.2018.10.003
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ISSN of the journal0955-0674
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