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Scientific article
Review
Open access
French

Caractères physicochimiques des principes actifs : leurs conséquences sur la faisabilité et la stabilité des formes galéniques

ContributorsDoelker, Eric
Published inSTP pharma pratiques, vol. 9, no. 5, p. 399-409
Publication date1999
Abstract

Depending on its origin or the particular batch, a given drug, although chemically well defined, may exhibit quite different behaviour. Process conditions (grinding, tabletting, granulation, drying) may also affect secondary (derived) properties of the drug, such as compactibility, wettability, solubility, dissolution rate, bioavailability and even pharmacological activity. Property changes may also be due to the storage conditions of the dosage form. In solids, these differences, which may exist initially or be generated by some treatment, arise directly from the primary characteristics of the crystals, i.e. the crystalline structure, both internal (polymorphism, pseudopolymorphism, amorphous state) and external (habitus, facies), crystal defects (dislocations) or the presence of impurities. In this respect, crystal « doping » by foreign substances may be envisaged as a means to improve drug properties of technological or biopharmaceutical interest. This review article explains these concepts using classical or more recently published examples from the literature.

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Keywords
  • Structure cristalline
  • Polymorphisme
  • Hydrates
  • Habitus cristallin
  • Défauts cristallins
  • Impuretés
  • Comprimabilité
  • Broyage
  • Compression
  • Granulation
  • Séchage
  • Conditions de conservation
  • Physique de l'état solide
  • Solvates
Citation (ISO format)
DOELKER, Eric. Caractères physicochimiques des principes actifs : leurs conséquences sur la faisabilité et la stabilité des formes galéniques. In: STP pharma pratiques, 1999, vol. 9, n° 5, p. 399–409.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
  • PID : unige:175003
ISSN of the journal1157-1497
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