en
Scientific article
Open access
English

Engineering a versatile and retrievable cell macroencapsulation device for the delivery of therapeutic proteins

Published iniScience, vol. 26, no. 8, 107372
Publication date2023-08-18
First online date2023-07-13
Abstract

Encapsulated cell therapy holds a great potential to deliver sustained levels of highly potent therapeutic proteins to patients and improve chronic disease management. A versatile encapsulation device that is biocompatible, scalable, and easy to administer, retrieve, or replace has yet to be validated for clinical applications. Here, we report on a cargo-agnostic, macroencapsulation device with optimized features for protein delivery. It is compatible with adherent and suspension cells, and can be administered and retrieved without burdensome surgical procedures. We characterized its biocompatibility and showed that different cell lines producing different therapeutic proteins can be combined in the device. We demonstrated the ability of cytokine-secreting cells encapsulated in our device and implanted in human skin to mobilize and activate antigen-presenting cells, which could potentially serve as an effective adjuvant strategy in cancer immunization therapies. We believe that our device may contribute to cell therapies for cancer, metabolic disorders, and protein-deficient diseases.

eng
Keywords
  • Natural sciences
  • Pharmaceutical science
  • Pharmacology
Funding
  • European Commission - A cancer vaccine to boost body’s natural defences to fight chordoma and head and neck cancer [880194]
Citation (ISO format)
GROGG, Julien et al. Engineering a versatile and retrievable cell macroencapsulation device for the delivery of therapeutic proteins. In: iScience, 2023, vol. 26, n° 8, p. 107372. doi: 10.1016/j.isci.2023.107372
Main files (1)
Article (Published version)
Secondary files (2)
Identifiers
ISSN of the journal2589-0042
16views
5downloads

Technical informations

Creation08/07/2023 6:47:27 AM
First validation02/20/2024 3:44:00 PM
Update time02/20/2024 3:44:00 PM
Status update02/20/2024 3:44:00 PM
Last indexation05/06/2024 5:58:04 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack