en
Scientific article
Review
Open access
English

Pathogenicity and virulence of hepatitis A virus

Published inVirulence, vol. 12, no. 1, p. 1174-1185
Publication date2021-12
Abstract

Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these different outcomes is unknown, but it is generally accepted that host factors such as the immunological status, age and the occurrence of underlaying hepatic diseases are the main determinants of the severity. However, it cannot be ruled out that some virus traits may also contribute to the severe clinical outcomes. In this review, we will analyze which genetic determinants of the virus may determine virulence, in the context of a paradigmatic virus in terms of its genomic, molecular, replicative, and evolutionary features.

eng
Keywords
  • CpG
  • HAV
  • IRES
  • Codon usage
  • Genomic composition
  • Naked virions
  • Quasi-enveloped virions
  • Child
  • Hepatitis A
  • Hepatitis A virus / genetics
  • Humans
  • Virulence
Affiliation Not a UNIGE publication
Citation (ISO format)
PINTÓ, Rosa et al. Pathogenicity and virulence of hepatitis A virus. In: Virulence, 2021, vol. 12, n° 1, p. 1174–1185. doi: 10.1080/21505594.2021.1910442
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Article (Published version)
Identifiers
ISSN of the journal2150-5594
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