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Scientific article
English

Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma

Published inCurrent medical research and opinion, vol. 26, no. 9, p. 2213-2219
Publication date2010-08-02
First online date2010-08-02
Abstract

Objective: To report the long-term effect of the dorzolamide/timolol (DTFC) and latanoprost/timolol (LTFC) fixed combinations on intraocular pressure (IOP) and visual field defects over time in naïve primary open-angle glaucoma (POAG) patients.

Study design and methods: Prospective, 4-year, open-label, interventional study.

Setting: high-volume outpatient clinic.

Patients: 178 patients were assigned to receive medical treatment with either DTFC or LTFC.

Intervention: over 4 years, tri-monthly IOP and yearly visual field assessment (Octopus 101, Program G2). outcomes: effect of treatment on IOP, visual field indices mean defect (MD), and visual field indices variance loss (VL) over time.

Results: DTFC and LTFC significantly (p < or = 0.001) reduced mean IOP over time (from 22.6 +/- 3.0 to 13.8 +/- 1.9 mmHg and from 22.3 +/- 4.0 to 14.7 +/- 1.9 mmHg, respectively). In all, 56 patients (70.9%) and 14 (17.9%) showed a significant MD improvement in the DTFC- and LTFC-treated groups, respectively, p = 0.0001. DTFC progressively and significantly decreased mean VL (from 30.21 +/- 23.88 to 8.11 +/- 8.50 dB). Mean sensitivity slopes during follow-up were 1.14 dB/year and -0.34 dB/year for DTFC and LTFC treatment groups, respectively; p = 0.028.

Conclusion: Both treatments significantly reduced IOP as compared with baseline. Additionally, treatment with dorzolamide/timolol fixed combination seem to be effective in preventing glaucomatous visual field progression. This study has some limitations that should be noted, among them its open-label design.

eng
Keywords
  • Dorzolamide/timolol
  • Fixed-combination therapies
  • Glaucoma
  • Latanoprost/timolo
Affiliation Not a UNIGE publication
Citation (ISO format)
PAJIC, Bojan, PAJIC-EGGSPUEHLER, B., HÄFLIGER, I.o. Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. In: Current medical research and opinion, 2010, vol. 26, n° 9, p. 2213–2219. doi: 10.1185/03007995.2010.508702
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ISSN of the journal0300-7995
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