CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients

Chavaz, Lara Marie; Royston, Lena; Masouridi Levrat, Stavroula; Mamez, Anne-Claire; Giannotti, Federica; Morin, Sarah; Van Delden, Christian; Chalandon, Yves; Neofytos, Dionysios

doi:10.1093/ofid/ofad169

Scientific article

English

CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients

ContributorsChavaz, Lara Marie

; Royston, Lena; Masouridi Levrat, Stavroula; Mamez, Anne-Claire; Giannotti, Federica; Morin, Sarah; Van Delden, Christian; Chalandon, Yves

; Neofytos, Dionysios

Published inOpen forum infectious diseases, vol. 10, no. 4, ofad169

Publication date2023-04-01

First online date2023-03-27

Abstract

In this single-center study of 61 allogeneic hematopoietic cell transplant (HCT) recipients receiving letermovir primary cytomegalovirus (CMV) prophylaxis for the first 100 days, we report 23% incidence of clinically significant CMV infection during the first 100 days after letermovir discontinuation, predominately in haploidentical HCT recipients, without any associations with CMV-DNAemia under letermovir.

Keywords

Allogeneic hematopoietic cell transplant recipients (allo-HCTr)
Breakthrough infection
Cytomegalovirus (CMV)
Letermovir
Prophylaxis
Risk factors

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

CHAVAZ, Lara Marie et al. CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients. In: Open forum infectious diseases, 2023, vol. 10, n° 4, p. ofad169. doi: 10.1093/ofid/ofad169

Article (Published version)

CC BY-NC-ND-4.0

Identifiers

PID : unige:174838
DOI : 10.1093/ofid/ofad169
PMID : 37125233
PMCID : PMC10147386

Additional URL for this publicationhttps://academic.oup.com/ofid/article/doi/10.1093/ofid/ofad169/7086693

Journal ISSN2328-8957

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CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients

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