en
Scientific article
Review
Open access
English

Molecular mechanisms of chemotropism and cell fusion in unicellular fungi

ContributorsMartin, Sophieorcid
Published inJournal of cell science, vol. 132, no. 11, jcs230706
Publication date2019-06-01
First online date2019-05-31
Abstract

In all eukaryotic phyla, cell fusion is important for many aspects of life, from sexual reproduction to tissue formation. Fungal cells fuse during mating to form the zygote, and during vegetative growth to connect mycelia. Prior to fusion, cells first detect gradients of pheromonal chemoattractants that are released by their partner and polarize growth in their direction. Upon pairing, cells digest their cell wall at the site of contact and merge their plasma membrane. In this Review, I discuss recent work on the chemotropic response of the yeast models Saccharomyces cerevisiae and Schizosaccharomyces pombe, which has led to a novel model of gradient sensing: the cell builds a motile cortical polarized patch, which acts as site of communication where pheromones are released and sensed. Initial patch dynamics serve to correct its position and align it with the gradient from the partner cell. Furthermore, I highlight the transition from cell wall expansion during growth to cell wall digestion, which is imposed by physical and signaling changes owing to hyperpolarization that is induced by cell proximity. To conclude, I discuss mechanisms of membrane fusion, whose characterization remains a major challenge for the future.

eng
Keywords
  • Cdc42
  • Cell fusion
  • Cell polarity
  • Chemotropism
  • MAPK
  • Pheromone gradient
  • S. cerevisiae
  • S. pombe
Affiliation Not a UNIGE publication
Citation (ISO format)
MARTIN, Sophie. Molecular mechanisms of chemotropism and cell fusion in unicellular fungi. In: Journal of cell science, 2019, vol. 132, n° 11, p. jcs230706. doi: 10.1242/jcs.230706
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0021-9533
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