Failure of human rhombic lip differentiation underlies medulloblastoma formation
ContributorsHendrikse, Liam D![orcid](assets/images/orcid.png)
; Haldipur, Parthiv; Saulnier, Olivier![orcid](assets/images/orcid.png)
; Millman, Jake; Sjoboen, Alexandria H; Erickson, Anders W![orcid](assets/images/orcid.png)
; Ong, Winnie; Gordon, Victor; Coudière-Morrison, Ludivine; Mercier, Audrey L![orcid](assets/images/orcid.png)
; Shokouhian, Mohammad![orcid](assets/images/orcid.png)
; Suárez, Raúl A; Ly, Michelle; Borlase, Stephanie; Scott, David S; Vladoiu, Maria C; Farooq, Hamza; Sirbu, Olga; Nakashima, Takuma![orcid](assets/images/orcid.png)
; Nambu, Shohei; Funakoshi, Yusuke; Bahcheli, Alec; Diaz-Mejia, J Javier![orcid](assets/images/orcid.png)
; Golser, Joseph; Bach, Kathleen; Phuong-Bao, Tram; Skowron, Patryk; Wang, Evan Y![orcid](assets/images/orcid.png)
; Kumar, Sachin A![orcid](assets/images/orcid.png)
; Balin, Polina; Visvanathan, Abhirami; Lee, John J Y; Ayoub, Ramy![orcid](assets/images/orcid.png)
; Chen, Xin![orcid](assets/images/orcid.png)
; Chen, Xiaodi; Mungall, Karen L; Luu, Betty; Bérubé, Pierre![orcid](assets/images/orcid.png)
; Wang, Yu C; Pfister, Stefan M![orcid](assets/images/orcid.png)
; Kim, Seung-Ki; Delattre, Olivier![orcid](assets/images/orcid.png)
; Bourdeaut, Franck; Doz, François; Masliah-Planchon, Julien; Grajkowska, Wieslawa A; Loukides, James; Dirks, Peter![orcid](assets/images/orcid.png)
; Fèvre-Montange, Michelle; Jouvet, Anne; French, Pim J![orcid](assets/images/orcid.png)
; Kros, Johan M; Zitterbart, Karel; Bailey, Swneke D; Eberhart, Charles G; Rao, Amulya A N; Giannini, Caterina![orcid](assets/images/orcid.png)
; Olson, James M![orcid](assets/images/orcid.png)
; Garami, Miklós![orcid](assets/images/orcid.png)
; Hauser, Peter; Phillips, Joanna J![orcid](assets/images/orcid.png)
; Ra, Young S; de Torres, Carmen; Mora, Jaume; Li, Kay K W; Ng, Ho-Keung; Poon, Wai S; Pollack, Ian F; López-Aguilar, Enrique; Gillespie, G Yancey; Van Meter, Timothy E![orcid](assets/images/orcid.png)
; Shofuda, Tomoko; Vibhakar, Rajeev![orcid](assets/images/orcid.png)
; Thompson, Reid C; Cooper, Michael K; Rubin, Joshua B![orcid](assets/images/orcid.png)
; Kumabe, Toshihiro; Jung, Shin; Lach, Boleslaw; Iolascon, Achille; Ferrucci, Veronica; de Antonellis, Pasqualino![orcid](assets/images/orcid.png)
; Zollo, Massimo![orcid](assets/images/orcid.png)
; Cinalli, Giuseppe![orcid](assets/images/orcid.png)
; Robinson, Shenandoah; Stearns, Duncan S; Van Meir, Erwin G; Porrati, Paola; Finocchiaro, Gaetano; Massimino, Maura; Carlotti, Carlos G; Faria, Claudia C; Roussel, Martine F![orcid](assets/images/orcid.png)
; Boop, Frederick; Chan, Jennifer A; Aldinger, Kimberly A![orcid](assets/images/orcid.png)
; Razavi, Ferechte; Silvestri, Evelina; McLendon, Roger E; Thompson, Eric M![orcid](assets/images/orcid.png)
; Ansari Djaberi, Marc Georges; Garre, Maria L; Chico, Fernando; Eguía, Pilar; Pérezpeña, Mario; Morrissy, A Sorana; Cavalli, Florence M G; Wu, Xiaochong; Daniels, Craig; Rich, Jeremy N; Jones, Steven J M; Moore, Richard A; Marra, Marco A; Huang, Xi; Reimand, Jüri; Sorensen, Poul H; Wechsler-Reya, Robert J; Weiss, William A; Pugh, Trevor J; Garzia, Livia; Kleinman, Claudia L; Stein, Lincoln D; Jabado, Nada; Malkin, David; Ayrault, Olivier; Golden, Jeffrey A; Ellison, David W; Doble, Brad; Ramaswamy, Vijay; Werbowetski-Ogilvie, Tamra E; Suzuki, Hiromichi; Millen, Kathleen J; Taylor, Michael D
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Published inNature, vol. 609, no. 7929, p. 1021-1028
Publication date2022-09
First online date2022-09-21
Abstract
Keywords
- Cell Differentiation / genetics
- Cell Lineage
- Cerebellar Neoplasms / classification
- Cerebellar Neoplasms / genetics
- Cerebellar Neoplasms / pathology
- Cerebellum / embryology
- Cerebellum / pathology
- Core Binding Factor alpha Subunits / genetics
- Hedgehog Proteins / metabolism
- Histone Demethylases
- Humans
- Ki-67 Antigen / metabolism
- Medulloblastoma / classification
- Medulloblastoma / genetics
- Medulloblastoma / pathology
- Metencephalon / embryology
- Metencephalon / pathology
- Muscle Proteins
- Mutation
- Otx Transcription Factors / deficiency
- Otx Transcription Factors / genetics
- Repressor Proteins
- T-Box Domain Proteins / metabolism
- Transcription Factors
Research group
Citation (ISO format)
HENDRIKSE, Liam D et al. Failure of human rhombic lip differentiation underlies medulloblastoma formation. In: Nature, 2022, vol. 609, n° 7929, p. 1021–1028. doi: 10.1038/s41586-022-05215-w
Main files (1)
Article (Accepted version)
![accessLevelPublic](assets/images/access-level-free.png)
Identifiers
- PID : unige:174532
- DOI : 10.1038/s41586-022-05215-w
- PMID : 36131014
- PMCID : PMC10026724
Commercial URLhttps://www.nature.com/articles/s41586-022-05215-w
ISSN of the journal0028-0836