Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and gem‐Dialkyl Vinyl Oxetanes

Montagnon, Claire; Pertschi, Romain; Besnard, Céline; Lacour, Jérôme

doi:10.1002/adsc.202301399

Scientific article

Open access

English

Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and gem‐Dialkyl Vinyl Oxetanes

ContributorsMontagnon, Claire

; Pertschi, Romain; Besnard, Céline; Lacour, Jérôme

Published inAdvanced synthesis & catalysis, adsc.202301399

Publication date2024-01-14

First online date2024-01-14

Abstract

Thanks to an unprecedented gem‐dialkyl substituent effect, an efficient synthesis of tetrahydro oxepine derivatives is achieved by ring expansion of vinyl oxetanes using acceptor (acceptor) diazo reagents under Cu(II)‐catalysis. A large scope of 2‐vinyl oxetanes and either diazo mono or diester reagents give access to a series of functionalized oxepines

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Research group

Citation (ISO format)

MONTAGNON, Claire et al. Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and gem‐Dialkyl Vinyl Oxetanes. In: Advanced synthesis & catalysis, 2024, p. adsc.202301399. doi: 10.1002/adsc.202301399

Article (Published version)

CC BY-4.0

Identifiers

PID : unige:174386
DOI : 10.1002/adsc.202301399

Commercial URLhttps://onlinelibrary.wiley.com/doi/10.1002/adsc.202301399

ISSN of the journal1615-4150

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Creation2024/01/23 14:33:16

First validation2024/01/24 13:58:39

Update time2024/03/13 13:17:28

Status update2024/03/13 13:17:28

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Selective Synthesis of Tetrahydro Oxepines by Cu‐Catalyzed Condensations of Diazomalonates and gem‐Dialkyl Vinyl Oxetanes

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