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Toward a Biophysically Plausible Bidirectional Hebbian Rule

Contributors

Grzywacz, Norberto M.; Burgi, Pierre-Yves

Published in

Neural computation, vol. 10, no. 3, p. 499-520

Publication date

1998

Abstract

Although the commonly used quadratic Hebbian–anti-Hebbian rules lead to successful models of plasticity and learning, they are inconsistent with neurophysiology. Other rules, more physiologically plausible, fail to specify the biological mechanism of bidirectionality and the biological mechanism that prevents synapses from changing from excitatory to inhibitory, and vice versa. We developed a synaptic bidirectional Hebbian rule that does not suffer from these problems. This rule was compared with physiological homosynaptic conditions in the hippocampus, with the results indicating the consistency of this rule with long-term potentiation (LTP) and long-term depression (LTD) phenomenologies. The phenomenologies considered included the reversible dynamics of LTP and LTD and the effects of N-methyl-D-aspartate blockers and phosphatase inhibitors.

Keywords

  • long-term potentiation (LTP)
  • long-term depression (LTD)
  • BCM rule
  • Hebbian mechanism
  • enzymatic complex
  • synaptic strength
  • autocatalytic switch
  • self-phosphorylation
  • short-term potentiation
  • bidirectional Hebbian Rule

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

GRZYWACZ, Norberto M., BURGI, Pierre-Yves. Toward a Biophysically Plausible Bidirectional Hebbian Rule. In: Neural computation, 1998, vol. 10, n° 3, p. 499–520. doi: 10.1162/089976698300017629

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0899-7667
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559downloads

Technical informations

Creation

16/11/2011 22:35:00

First validation

16/11/2011 22:35:00

Update

14/10/2025 00:28:38

Status update

14/03/2023 17:04:18

Last indexation

31/08/2026 11:38:06
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