Scientific article
Open access

Time‑of‑flight and black‑blood MRI to study intracranial arteries in rats

Published inEuropean radiology experimental, vol. 8, no. 1, 3
First online date2024-01-09

Intracranial aneurysms (IAs) are usually incidentally discovered by magnetic resonance imaging (MRI). Once discovered,

the risk associated with their treatment must be balanced with the risk of an unexpected rupture. Although clinical

observations suggest that the detection of contrast agent in the aneurysm wall using a double-inversion recovery

black-blood (BB) sequence may point to IA wall instability, the exact meaning of this observation is not understood.

Validation of reliable diagnostic markers of IA (in)stability is of utmost importance to deciding whether to treat

or not an IA. To longitudinally investigate IA progression and enhance our understanding of this devastating disease,

animal models are of great help. The aim of our study was to improve a three-dimensional (3D)-time-of-flight (TOF)

sequence and to develop a BB sequence on a standard preclinical 3-T MRI unit to investigate intracranial arterial

diseases in rats. We showed that our 3D-TOF sequence allows reliable measurements of intracranial artery diameters,

inter-artery distances, and angles between arteries and that our BB sequence enables us to visualize intracranial arteries.

We report the first BB-MRI sequence to visualize intracranial arteries in rats using a preclinical 3-T MRI unit. This

sequence could be useful for a large community of researchers working on intracranial arterial diseases.

  • Aneurysm
  • Intracranial arterial diseases
  • Magnetic resonance angiography
  • Magnetic resonance imaging
  • Rats
Citation (ISO format)
CAYRON, Anne France Judith et al. Time‑of‑flight and black‑blood MRI to study intracranial arteries in rats. In: European radiology experimental, 2024, vol. 8, n° 1, p. 3. doi: 10.1186/s41747-023-00407-z
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Article (Published version)
ISSN of the journal2509-9280

Technical informations

Creation01/09/2024 7:30:56 AM
First validation01/16/2024 9:11:03 AM
Update time01/16/2024 9:11:03 AM
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