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Scientific article
Open access
English

Severe SARS‑CoV‑2 infection as a marker of undiagnosed cancer: a population‑based study

Published inScientific reports, vol. 13, 8729
Publication date2023-05-30
First online date2023-05-30
Abstract

No study has yet investigated if a severe SARS-CoV-2 infection represents a marker of an undiagnosed cancer. This population-based study, using the SNDS database, identified from 02/15/2020 to 08/31/2021, 41,302 individuals hospitalized in intensive care unit due to SARS-CoV-2 (ICU-gr) and 713,670 control individuals not hospitalized for SARS-CoV-2 (C-gr). Individuals were matched according to year of birth, sex and French department. The cancer incidence was compared in the two groups during the follow-up period (index date-12/31/2021), using Cox proportional hazards models adjusted on matching variables, socioeconomic characteristics and comorbidities. In the ICU-gr, 2.2% (n = 897) was diagnosed with a cancer in the following months, compared to 1.5% (n = 10,944) in the C-gr. The ICU-gr had a 1.31 higher risk of being diagnosed with a cancer following hospital discharge compared to the C-gr (aHR 1.31, 95% CI 1.22-1.41). A global similar trend was found when competing risk of death was taken into account (aHR 1.25, 95% CI 1.16-1.34). A significant higher risk was found concerning renal (aHR 3.16, 95% CI 2.33-4.27), hematological (aHR 2.54, 95% CI 2.07-3.12), colon (aHR 1.72, 95% CI 1.34-2.21), and lung (aHR 1.70, 95% CI 1.39-2.08) cancers. This suggests that a severe SARS-CoV-2 infection may represent a marker of an undiagnosed cancer.

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Keywords
  • SARS-CoV-2, COVID-19, cancer
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology
  • Humans
  • Neoplasms / diagnosis
  • Neoplasms / epidemiology
  • SARS-CoV-2
  • COVID-19
  • Cancer
Citation (ISO format)
DUGERDIL, Adeline et al. Severe SARS‑CoV‑2 infection as a marker of undiagnosed cancer: a population‑based study. In: Scientific reports, 2023, vol. 13, p. 8729. doi: 10.1038/s41598-023-36013-7
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ISSN of the journal2045-2322
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Creation11/22/2023 1:00:53 PM
First validation12/21/2023 1:21:38 PM
Update time12/21/2023 1:21:38 PM
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