Cellular senescence: lessons from yeast for human aging?

Shore, David M.

doi:10.1016/s0960-9822(98)70122-8

Scientific article

Review

English

Cellular senescence: lessons from yeast for human aging?

ContributorsShore, David M.

Published inCurrent biology, vol. 8, no. 6, p. R192-R195

Publication date1998-03-12

Abstract

Recent results point to an important role for the nucleolus in the senescence of yeast cells. A further report suggests that the formation and preferential accumulation in mother cells of extrachromosomal rDNA circles is a cause of aging in yeast; this may be an ancient and conserved mechanism of senescence.

Keywords

Aging
Cell Nucleolus / genetics
Cellular Senescence / genetics
DNA-Binding Proteins / biosynthesis
DNA-Binding Proteins / physiology
Extrachromosomal Inheritance / genetics
Fungal Proteins / physiology
Humans
Saccharomyces cerevisiae / physiology
Telomere / genetics
Trans-Activators / physiology

Affiliation entities

Faculté des sciences / Section de biologie / Département de biologie moléculaire

Citation (ISO format)

SHORE, David M. Cellular senescence: lessons from yeast for human aging? In: Current biology, 1998, vol. 8, n° 6, p. R192–R195. doi: 10.1016/s0960-9822(98)70122-8

Article (Published version)

CC BY-4.0

Identifiers

PID : unige:173798
DOI : 10.1016/s0960-9822(98)70122-8
PMID : 9512411

Journal ISSN0960-9822

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Cellular senescence: lessons from yeast for human aging?

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