Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Durier, Christine; Ninove, Laetitia; Lefebvre, Maeva; Radenne, Anne; Desaint, Corinne; Ropers, Jacques; Bauer, Rebecca; Lebbah, Said; Carette, Diane; Lachatre, Marie; Lecompte, Anne-Sophie; Deplanque, Dominique; Botelho-Nevers, Elisabeth; Conrad, Anne; Dussol, Bertrand; Maakaroun-Vermesse, Zoha; Melica, Giovanna; Nicolas, Jean-François; Verdon, Renaud; Kiladjian, Jacques; Loubet, Paul; Schmidt-Mutter, Catherine; Dualé, Christian; Ansart, Séverine; Priet, Stéphane; Levier, Axel; Molino, Diana; Vieillard, Louis-Victorien; Parfait, Béatrice; Lelièvre, Jean-Daniel; Tartour, Eric; de Lamballerie, Xavier; Launay, Odile; ANRS0002S CoviCompareP Group; AP-HP CoviCompareM Group

doi:10.1038/s41598-022-24409-w

Scientific article

English

Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

CollaboratorsEberhardt, Christiane Sigrid; Siegrist, Claire-Anne

Published inScientific reports, vol. 12, no. 1, 20373

Publication date2022-11-27

First online date2022-11-27

Abstract

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.

Keywords

Humans
Aged
Aged, 80 and over
Antibodies, Neutralizing
SARS-CoV-2 / genetics
Neutralization Tests
Antibodies, Viral
RNA, Messenger
Viral Vaccines
COVID-19 / prevention & control
Vaccination

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Centre de vaccinologie et d'immunologie néonatale (177)

Citation (ISO format)

DURIER, Christine et al. Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years. In: Scientific reports, 2022, vol. 12, n° 1, p. 20373. doi: 10.1038/s41598-022-24409-w

Article (Published version)

CC BY-4.0

Identifiers

PID : unige:173792
DOI : 10.1038/s41598-022-24409-w
PMID : 36437298
PMCID : PMC9701678

Journal ISSN2045-2322

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Creation12/09/2023 10:00:39

First validation15/12/2023 08:48:16

Update time15/12/2023 08:48:16

Status update15/12/2023 08:48:16

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Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

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