Proceedings chapter
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English

Poly (ortho esters) implants for the sustained delivery of a protein factors influencing the release behaviour of BSA in vitro

Presented atParis, 7-13 July 2000
PublisherDeerfield : Controlled Release Society
Publication date2000
Abstract

Peptides and proteins have received much attention in recent years as drug candidates. Unfortunately, most of these drugs cannot produce their full therapeutic effects when administered by the parenteral route, owing to their extremely short-lived biological activity. A variety of bioresorbable polymers have been used as matrices for controlled release delivery systems, for parenteral applications. Among them, a new family of poly(ortho esters) (POE IV), based on the reaction between a diketene acetal and two types of diols, where one diol has been modified by the incorporation of a short lactide or glycolide segment, is of great interest [2,3]. These polymers soften and melt on heating and can potentially be shaped in a variety of implants using several molding techniques. The goal of the present research was to develop biodegradable implants suitable for the delivery of proteins. For this purpose, we prepared small rods containing labelled bovine serum albumin (BSA-FITC) as model protein.

Citation (ISO format)
ROTHEN-WEINHOLD, Alexandra Laurence et al. Poly (ortho esters) implants for the sustained delivery of a protein factors influencing the release behaviour of BSA in vitro. In: The 27th International Symposium on Controlled Release of Bioactive Materials and the Third Consumer and Diversified Products Conference. Paris. Deerfield : Controlled Release Society, 2000. p. 968–969.
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