Scientific article
English

Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair

Publication date2015-12-28
First online date2015-12-28
Abstract

Parasites of phylum Apicomplexa cause significant morbidity and mortality on a global scale. Central to the pathogenesis of these parasites is their ability to invade host cells through a junction formed by members of the apical membrane antigen (AMA) and rhoptry neck protein 2 (RON2) families localized to the parasite surface and host outer membrane, respectively. Here we structurally and functionally characterize Toxoplasma gondii AMA4 ( Tg AMA4), a highly divergent AMA protein. Structural analyses of Tg AMA4 in the apo and RON2 L1 bound forms reveal a previously underappreciated level of molecular diversity at the parasite–host-cell interface that offers important insight into stage-dependent invasion strategies and yields a more comprehensive model of apicomplexan invasion.

Keywords
  • Apicomplexa
  • Toxoplasma gondii
  • X-ray crystallography
  • Invasion
  • Moving junction
Affiliation entities Not a UNIGE publication
Citation (ISO format)
PARKER, Michelle L. et al. Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair. In: Proceedings of the National Academy of Sciences of the United States of America, 2015, vol. 113, n° 2, p. 398–403. doi: 10.1073/pnas.1515898113
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Article (Published version)
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Identifiers
ISSN of the journal0027-8424
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