Scientific article
Open access

An Approach to Quantifying the Interaction between Behavioral and Transmission Clusters

Published inViruses, vol. 14, no. 4, 784
Publication date2022-04-10
First online date2022-04-10

We hypothesize that patterns of sexual behavior play a role in the conformation of transmission networks, i.e., the way you behave might influence whom you have sex with. If that was the case, behavioral grouping might in turn correlate with, and potentially predict transmission networking, e.g., proximity in a viral phylogeny. We rigorously present an intuitive approach to address this hypothesis by quantifying mapped interactions between groups defined by similarities in sexual behavior along a virus phylogeny while discussing power and sample size considerations. Data from the Swiss HIV Cohort Study on condom use and hepatitis C virus (HCV) sequences served as proof-of-concept. In this case, a strict inclusion criteria contrasting with low HCV prevalence hindered our possibilities to identify significant relationships. This manuscript serves as guide for studies aimed at characterizing interactions between behavioral patterns and transmission networks. Large transmission networks such as those of HIV or COVID-19 are prime candidates for applying this methodological approach.

  • Clusters
  • Hepatitis C virus
  • Sexual behavior
  • Transmission networks
  • COVID-19 / epidemiology
  • Cohort Studies
  • HIV Infections
  • Hepacivirus / genetics
  • Hepatitis C
  • Homosexuality, Male
  • Humans
  • Male
  • Phylogeny
  • Prevalence
Research group
Citation (ISO format)
SALAZAR-VIZCAYA, Luisa et al. An Approach to Quantifying the Interaction between Behavioral and Transmission Clusters. In: Viruses, 2022, vol. 14, n° 4, p. 784. doi: 10.3390/v14040784
Main files (1)
Article (Published version)
Secondary files (1)
ISSN of the journal1999-4915

Technical informations

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