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Scientific article
English

Novel Spironucleosides: 1″,3″-Thiazolidine-2″-Spiro-3′-3′-Deoxyuridine Derivatives

Published inNucleosides & nucleotides, vol. 17, no. 6, p. 1115-1123
Publication date1998-06
First online date2006-08-21
Abstract

Reaction of 2′,5′-di-O-TBDMS-3′-ketouridine 1 with L-cysteine yielded in good yield a resolvable mixture of the two expected epimeric spironucleosides 2 and 3. Amidification of their carboxylic group took place readily and the ribo carboxamide 4 was oxidized to the corresponding sulfoxide 6. Despite their similarity to TSAO derivatives these compounds did not exhibit usable anti-HIV activity.

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Citation (ISO format)
TRONCHET, Jean Marcel Julien et al. Novel Spironucleosides: 1″,3″-Thiazolidine-2″-Spiro-3′-3′-Deoxyuridine Derivatives. In: Nucleosides & nucleotides, 1998, vol. 17, n° 6, p. 1115–1123. doi: 10.1080/07328319808004224
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ISSN of the journal0732-8311
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