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Scientific article
Review
Open access
English

The current pediatric perspective on type B and C hepatic encephalopathy

Published inAnalytical biochemistry, vol. 643, 114576
Publication date2022-04-15
First online date2022-01-29
Abstract

That children present with hepatic encephalopathy (HE) in the setting of acute liver failure (ALF) is accepted and a recognized prognostic factor for survival [1,2]. What is less understood is the impact of chronic liver disease (CLD) on the neuro-cognitive and -psychiatric development and outcomes of children with chronic liver disease early in life. Much is extrapolated from the adult literature or from work in experimental models. But what distinguishes children is that central nervous system development, characterized by massive brain growth, is ongoing at the time of liver disease, arguably exposing them to unique risks, something which cannot be extrapolated from adults. The purpose of this brief review is to summarize what is distinctive about the neurocognition of children with CLD or having presented CLD or portosystemic bypass in childhood.

eng
Keywords
  • Ammonium
  • Children
  • Chronic liver disease
  • Encephalopathy
  • Glutamine
  • Portosystemic shunting
  • Type B
  • Type C
  • Child
  • Hepatic Encephalopathy / diagnosis
  • Humans
  • Liver Failure, Acute / diagnosis
Citation (ISO format)
MCLIN, Valérie Anne, D’ANTIGA, Lorenzo. The current pediatric perspective on type B and C hepatic encephalopathy. In: Analytical biochemistry, 2022, vol. 643, p. 114576. doi: 10.1016/j.ab.2022.114576
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Article (Published version)
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ISSN of the journal0003-2697
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