Article (Author postprint) (202 Kb) - 
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Scientific Article
unige:1719 
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Multiple ADH genes are associated with upper aerodigestive cancers |
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| Authors | ||
| Published in | Nature genetics. 2008, vol. 40, no. 6, p. 707-9 | |
| Abstract | Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology. | |
| Keywords | Adult — Age Distribution — Alcohol Dehydrogenase/genetics — Alcohol Drinking — Alcohol-Induced Disorders/epidemiology/genetics — Case-Control Studies — Esophageal Neoplasms/epidemiology/genetics — Female — Genetic Predisposition to Disease — Genotype — Humans — Laryngeal Neoplasms/epidemiology/genetics — Male — Middle Aged — Models, Biological — Oropharyngeal Neoplasms/epidemiology/genetics — Polymorphism, Single Nucleotide — Risk Factors | |
| Identifiers | DOI: 10.1038/ng.151 PMID: 18500343 | |
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Article (Author postprint) (202 Kb) - Limited access to UNIGE Other version: http://www.nature.com/ng/journal/v40/n6/full/ng.151.html |
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| Structures | ||
| Research group | Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532) | |
| Citation (ISO format) | HASHIBE, Mia, BENHAMOU, Simone, BOUCHARDY MAGNIN, Christine. Multiple ADH genes are associated with upper aerodigestive cancers. In: Nature genetics, 2008, vol. 40, n° 6, p. 707-9. https://archive-ouverte.unige.ch/unige:1719 |
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