Multiple ADH genes are associated with upper aerodigestive cancers

Hashibe, Mia; McKay, James D; Curado, Maria Paula; Oliveira, Jose Carlos; Koifman, Sergio; Koifman, Rosalina; Zaridze, David; Shangina, Oxana; Wünsch-Filho, Victor; Eluf-Neto, Jose; Levi, Jose Eduardo; Matos, Elena; Lagiou, Pagona; Lagiou, Areti; Benhamou, Simone; Bouchardy Magnin, Christine; Szeszenia-Dabrowska, Neonilia; Menezes, Ana; Mór Dall’Agnol, Marinel; Merletti, Franco; Richiardi, Lorenzo; Fernandez, Leticia; Lence, Juan; Talamini, Renato; Barzan, Luigi; Mates, Dana; Mates, Ioan Nicolae; Kjaerheim, Kristina; Macfarlane, Gary J; Macfarlane, Tatiana V; Simonato, Lorenzo; Canova, Cristina; Holcátova, Ivana; Agudo, Antonio; Castellsagué, Xavier; Lowry, Ray; Janout, Vladimir; Kollarova, Helena; Conway, David I; McKinney, Patricia A; Znaor, Ariana; Fabianova, Eleonora; Bencko, Vladimir; Lissowska, Jolanta; Chabrier, Amelie; Hung, Rayjean J; Gaborieau, Valerie; Boffetta, Paolo; Brennan, Paul

doi:10.1038/ng.151

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Title		Multiple ADH genes are associated with upper aerodigestive cancers
Authors		Hashibe, Mia McKay, James D Curado, Maria Paula Oliveira, Jose Carlos Koifman, Sergio Koifman, Rosalina Zaridze, David Shangina, Oxana Wünsch-Filho, Victor Eluf-Neto, Jose Levi, Jose Eduardo Matos, Elena Lagiou, Pagona Lagiou, Areti Benhamou, Simone Bouchardy Magnin, Christine Szeszenia-Dabrowska, Neonilia Menezes, Ana Mór Dall’Agnol, Marinel Merletti, Franco Richiardi, Lorenzo Fernandez, Leticia Lence, Juan Talamini, Renato Barzan, Luigi Mates, Dana Mates, Ioan Nicolae Kjaerheim, Kristina Macfarlane, Gary J Macfarlane, Tatiana V Simonato, Lorenzo Canova, Cristina Holcátova, Ivana Agudo, Antonio Castellsagué, Xavier Lowry, Ray Janout, Vladimir Kollarova, Helena Conway, David I McKinney, Patricia A Znaor, Ariana Fabianova, Eleonora Bencko, Vladimir Lissowska, Jolanta Chabrier, Amelie Hung, Rayjean J Gaborieau, Valerie Boffetta, Paolo Brennan, Paul show all authors [1 - 49]
Published in		Nature genetics. 2008, vol. 40, no. 6, p. 707-709
Abstract		Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
Keywords		Adult — Age Distribution — Alcohol Dehydrogenase/genetics — Alcohol Drinking — Alcohol-Induced Disorders/epidemiology/genetics — Case-Control Studies — Esophageal Neoplasms/epidemiology/genetics — Female — Genetic Predisposition to Disease — Genotype — Humans — Laryngeal Neoplasms/epidemiology/genetics — Male — Middle Aged — Models, Biological — Oropharyngeal Neoplasms/epidemiology/genetics — Polymorphism, Single Nucleotide — Risk Factors
Identifiers		DOI: 10.1038/ng.151 PMID: 18500343
Full text		Article (Accepted version) (202 Kb) - Limited access to UNIGE Other version: http://www.nature.com/ng/journal/v40/n6/full/ng.151.html
Structures		Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale / Registre genevois des tumeurs
Research group		Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Citation (ISO format)		HASHIBE, Mia et al. Multiple ADH genes are associated with upper aerodigestive cancers. In: Nature genetics, 2008, vol. 40, n° 6, p. 707-709. doi: 10.1038/ng.151 https://archive-ouverte.unige.ch/unige:1719