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Multiple ADH genes are associated with upper aerodigestive cancers

Hashibe, Mia
McKay, James D
Curado, Maria Paula
Oliveira, Jose Carlos
Koifman, Sergio
Koifman, Rosalina
Zaridze, David
Shangina, Oxana
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Published in Nature genetics. 2008, vol. 40, no. 6, p. 707-709
Abstract Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
Keywords AdultAge DistributionAlcohol Dehydrogenase/geneticsAlcohol DrinkingAlcohol-Induced Disorders/epidemiology/geneticsCase-Control StudiesEsophageal Neoplasms/epidemiology/geneticsFemaleGenetic Predisposition to DiseaseGenotypeHumansLaryngeal Neoplasms/epidemiology/geneticsMaleMiddle AgedModels, BiologicalOropharyngeal Neoplasms/epidemiology/geneticsPolymorphism, Single NucleotideRisk Factors
PMID: 18500343
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Research group Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
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HASHIBE, Mia et al. Multiple ADH genes are associated with upper aerodigestive cancers. In: Nature genetics, 2008, vol. 40, n° 6, p. 707-709. doi: 10.1038/ng.151 https://archive-ouverte.unige.ch/unige:1719

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Deposited on : 2009-05-26

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