en
Scientific article
English

Ca2+ Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in C. elegans

Published inNeuron, vol. 30, no. 1, p. 241-248
Publication date2001-04
Abstract

On a radial temperature gradient, C. elegans worms migrate, after conditioning with food, toward their cultivation temperature and move along this isotherm. This experience-dependent behavior is called isothermal tracking (IT). Here we show that the neuron-specific calcium sensor-1 (NCS-1) is essential for optimal IT. ncs-1 knockout animals show major defects in IT behavior, although their chemotactic, locomotor, and thermal avoidance behaviors are normal. The knockout phenotype can be rescued by reintroducing wild-type NCS-1 into the AIY interneuron, a key component of the thermotaxis network. A loss-of-function form of NCS-1 incapable of binding calcium does not restore IT, whereas NCS-1 overexpression enhances IT performance levels, accelerates learning (faster acquisition), and produces a memory with slower extinction. Thus, proper calcium signaling via NCS-1 defines a novel pathway essential for associative learning and memory.

eng
Citation (ISO format)
GOMEZ, Marie et al. Ca<sup>2+</sup> Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in <i>C.</i> <i>elegans</i>. In: Neuron, 2001, vol. 30, n° 1, p. 241–248. doi: 10.1016/S0896-6273(01)00276-8
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0896-6273
20views
0downloads

Technical informations

Creation10/03/2023 10:02:13 AM
First validation10/03/2023 10:14:26 AM
Update time10/03/2023 10:14:26 AM
Status update10/03/2023 10:14:26 AM
Last indexation01/18/2024 1:03:35 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack