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Novel micellar systems for the formulation of poorly water soluble drugs : biocompatibility aspects and pharmaceutical applications

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Defense Thèse de doctorat : Univ. Genève, 2010 - Sc. 4258 - 2010/10/15
Abstract Amongst the large number of novel drugs, 95% are lipophilic and poorly water soluble. Particularly, this renders their aqueous formulation very difficult. In this regard this thesis focused on polymeric micelles based on novel MPEG-hexPLA copolymers forming a hydrophilic shell and a very hydrophobic core that favors the incorporation of poorly water soluble drugs. Although the drug hydrophobicity and water solubility are the main parameters in respect to their incorporation efficiency, structural parameters showed an important influence, too. The biocompatibility of the novel MPEG-hexPLA micelles could be proven and promising pharmaceutical applications can be envisioned. An intravenous application for ovarian cancer diagnostics was demonstrated in vitro and in vivo in rats with the administration of a micelle formulation containing the fluorescent compound hypericin. A topical dermatology application with various antifungal compounds and possible use for oral delivery were also evidenced.
Keywords AntifungalBiocompatibilityCAMCyclosporin ADrug deliveryEconazole nitrateHexyl substituted polylactidesHypericinMicellesToxicityOvarian cancerHexPLAPhotodiagnosisPolymeric micellesSkin depositionTEMTopical application
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URN: urn:nbn:ch:unige-171669
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DUMONTET MONDON, Karine. Novel micellar systems for the formulation of poorly water soluble drugs : biocompatibility aspects and pharmaceutical applications. Université de Genève. Thèse, 2010. https://archive-ouverte.unige.ch/unige:17166

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Deposited on : 2011-10-12

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