Due to the high morbidity and mortality with limited life expectancy of dialysis patients, it is essential to implement advance care planning in order to know patients’ values and care preferences and respect their autonomy. However, advance care planning is rarely carried out, due to the difficulties in initiating end-of-life discussions, both by patients and healthcare professionals. The use of “serious games” in the form of card games has shown promise in supporting the implementation of advance care planning. In this article, we present the development process of an advance care planning intervention for dialysis patients using a card game (the Go Wish), in the Division of Nephrology of the University Hospitals of Geneva.