Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice

Weng, Kuo-Feng; Tee, Han Kang; Tseligka, Eirini; Cagno, Valeria; Mathez, Grégory Tristan; Rosset, Stéphane; Nagamine, Claude M.; Sarnow, Peter; Kirkegaard, Karla; Tapparel, Caroline

doi:10.1016/j.celrep.2023.112389

Scientific article

English

Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice

ContributorsWeng, Kuo-Feng; Tee, Han Kang; Tseligka, Eirini; Cagno, Valeria; Mathez, Grégory Tristan; Rosset, Stéphane; Nagamine, Claude M.; Sarnow, Peter; Kirkegaard, Karla; Tapparel, Caroline

Published inCell reports, vol. 42, no. 4, 112389

Publication date2023-04

Abstract

Keywords

B cell
CP: Immunology
CP: Microbiology
EV-A71
EV71
VP1
Enterovirus
Heparan sulfate
Mouse
Neutralizing antibody
Oral infection
Pathogenicity

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Research groups

Identification des facteurs clés impliqués dans la pathogénèse des rhinovirus et entérovirus (953)

Funding

Swiss National Science Foundation - Factors modulating rhinovirus and enterovirus pathogenicity [184777]

Citation (ISO format)

WENG, Kuo-Feng et al. Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice. In: Cell reports, 2023, vol. 42, n° 4, p. 112389. doi: 10.1016/j.celrep.2023.112389

Article (Published version)

CC BY-NC-ND-4.0

Identifiers

PID : unige:171555
DOI : 10.1016/j.celrep.2023.112389
PMID : 37058406

Additional URL for this publicationhttps://www.sciencedirect.com/science/article/pii/S221112472300400X

Journal ISSN2211-1247

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Creation18/09/2023 11:41:02

First validation20/09/2023 17:33:14

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Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice

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